Reproductive, Stem Cell and Perinatal Biology
Faculty & Staff

Dr. Virginia D. Winn joined the faculty in the summer of 2014 coming from University of Colorado School of Medicine. Her research program focuses on improving the health of mothers and their offspring. Central to this goal are her investigations of human placental development and the obstetrical complications associated with placental dysfunction. Current studies focus predominately on the pregnancy-specific condition known as preeclampsia, characterized by new onset hypertension and proteinuria in the second half of pregnancy. The placenta is the inciting organ for this condition as once the placenta delivers the disease resolves. Investigations include determining the role of a number of placental expressed preeclampsia-associated genes (Siglec-6, leptin and PAPP-A2) on trophoblast differentiation and invasion, which is often impaired in placentas of pregnancies complicated by preeclampsia. The laboratory also carries out studies to determine the role of endothelial progenitor cells in preeclampsia pathogenesis as well as determine biomarkers of disease. A second line of investigation focuses on determining the impact of pregnancy on the maternal immune system and dissecting the mechanism by which pregnancy ameliorates rheumatoid arthritis. These studies also address the mechanisms that allow for maternal-fetal tolerance. A recent line of investigation for Dr. Winn is developing methods to assess human placental function during an ongoing pregnancy through assessment of placental exosomes in the maternal blood. Learn more about Winn Lab here.

Dr. Bertha Chen’s research examines the molecular causes of urinary incontinence and pelvic floor dysfunction. Recognizing that urinary incontinence linked to demise of smooth muscle sphincter function, she is investigating the potential use of stem cell regeneration to restore muscle capacity.

Dr. Matteo A. Molè, PhD, is an Assistant Professor in the Department of Obstetrics and Gynecology at Stanford University. He is a member of the Division of Reproductive, Stem Cell and Perinatal Biology, as well as the Dunlevie Maternal-Fetal Medicine Center for Discovery, Innovation and Clinical Impact.

In the summer of 2023, Dr. Molè joined Stanford University as an Assistant Professor. His work focuses on investigating the mechanisms of human embryo implantation. The successful implantation of an embryo is crucial for the establishment of a healthy pregnancy. During the transition between the first and second week of gestation, the human embryo must securely implant into the maternal uterus, initiating development of the placenta to receive necessary nutrients and oxygen for its growth until birth.

Dr. Vittorio Sebastiano joined the faculty in the fall of 2014. The thread of Ariadne that connects germ cells, preimplantation development and pluripotent stem cells is the focus of research in the Sebastiano Lab. The zygote originates from the fusion of two highly specialized germ cells (the sperm and the oocyte) and in a few days develops into a blastocyst with a pluripotent cell population (the inner cell mass). These cells diverge from the extraembryonic cells of the trophoectoderm (will form the placenta) and can give rise to embryonic stem cells, in which a perpetual pluripotent and undifferentiated state is maintained. The long-term goals of the Sebastiano Lab include: 1) Understanding the biology of germ cells and a their ability to sustain early phases of preimplantation development; 2) Understanding the mechanisms that regulate very early cell fate decisions in human embryos and 3) Understanding the biology of Pluripotent Stem Cells and the mechanisms that lead to their formation also in the context of iPSCs derivation. Learn more about Sebastiano Lab here.

• Dr. Bo Yu, MD, MS is an Assistant Professor in the Division of REI, Department of OBGYN.  Dr. Yu received a master’s degree in Nutrition from Clemson University before starting her medical career. After graduating from University of Michigan Medical School with Distinction in Research, she completed her residency in OBGYN at Columbia University and subsequent REI fellowship at the NIH.  Dr. Yu received research training through the NIH-funded Reproductive Scientist Development Program (RSDP). Prior to joining Stanford, she was an Assistant Professor at Albert Einstein College of Medicine and University of Washington. Her clinical interests include female infertility, assisted reproductive technologies, and oncofertility. Learn more about Bo Yu's lab here.

Cynthia Klein
Senior Lab Manager

John Mendoza
Facilities Manager

Cindy Lee
Grants Manager

Delila Adams
Administrative Associate III