Maternal-Fetal Medicine and Obstetric Research

Stanford’s Division of Maternal-Fetal Medicine and Obstetrics has an outstanding record of scientific investigation. From early pregnancy and placentation studies to prenatal diagnosis and fetal therapy research, to clinical trials and cohort studies covering a broad spectrum of maternal-fetal and obstetrical complications. We are actively engaged in several national collaborative trials, including studies sponsored by the National Heart Lung and Blood Institute (NHLBI) and National Institute of Child Health and Human Development (NICHD). Our division is also a part of the North American Fetal Therapy Network (NAFTNet).

Our division’s excellence in scientific investigation exemplifies Stanford’s commitment to advancing maternal and child health.

For more information about any current or past research projects or inquiries about potential collaboration or participation, please contact the MFM research operations team.

Phone: (650) 725-5720

 

  1. Chronic Hypertension and Pregnancy (CHAP) Project:  A Pragmatic Multicenter Randomized Trial Antihypertensive Therapy for Mild Chronic Hypertension during Pregnancy

    Principal Investigator: Yasser El-Sayed, MD 

    The purpose of this study is to evaluate whether a blood pressure treatment to achieve targets recommended for non-pregnant adults (<140/90 mmHg) is also effective and safe during pregnancy. More information: chap.obgyn.uab.edu

  2. Childhood Pulmonary Complications in a Birth Cohort After a Randomized Trial of Antenatal Corticosteroids: The ALPS Follow-Up Study

    Principal Investigator: Yasser El-Sayed, MD

    The purpose of the study is to investigate the long-term respiratory outcomes among the birth cohort from ALPS study (randomized controlled trial of antenatal corticosteroids).

    More information: https://mfmunetwork.bsc.gwu.edu/PublicBSC/MFMU/MFMUPublic/

  3. Childhood Cognitive Function in a Birth Cohort after a Randomized Trial of Antenatal Corticosteroids: the ALPS Neurocognitive Follow-Up Study

    Principal Investigator: Yasser El-Sayed, MD

    The purpose of the study is to investigate the long-term cognitive outcomes among the birth cohort from ALPS study (randomized controlled trial of antenatal corticosteroids).

    More information: https://mfmunetwork.bsc.gwu.edu/PublicBSC/MFMU/MFMUPublic/

  4. Effect of Preeclampsia on Cardiovascular Health (EPOCH)

    Principal Investigators: Virginia D. Winn, MD PhD;  Mark Hlatky, MD

    The purpose of the study is to investigate the pathways across the life-course that link preeclampsia during pregnancy to cardiovascular health later in life.

  5. Cell Free DNA for Non-Invasive Prenatal Diagnosis in Pregnancy Complicated by Birth Defects

    Principal Investigator: Katherine Bianco, MD

    In order to improve the field of non-invasive prenatal screening and diagnosis, we aim to develop novel molecular approaches and improve the existing ones.

  6. Minimally Invasive Fetal Neural Tube Defect Repair Study

    Principal investigator: Yair Blumenfeld, MD

    The purpose of the study is to assess the feasibility, safety and clinical effectiveness of minimally invasive (fetoscopic) in-utero spina bifida repair, compared to the standard open (via hysterotomy) fetal repair or neonatal repair options.

  7. Clinical and Molecular Characterization of Placenta Accreta: A Prospective, Observational Study

    Principal Investigator: Deirdre Lyell, MD

    The information and samples from this study are being used to help researchers learn more about why placenta accreta develops in some women but not in others, and how best to care for women and their babies in pregnancies complicated by placenta accreta.

  8. Molecular Imaging Placental Function

    Principal Investigators: Virginia D Winn, MD, PhD; Julie Baker, PhD

    The purpose of this study is to develop technology to utilize circulating cell free DNA (cfDNA) in the maternal blood as a means to assess placental function non-invasively.

  9. North American Fetal Therapy Network (NAFTNet) Prenatal Diagnosis of Isolated Aqueductal Stenosis

    Principal Investigator: Yair Blumenfeld, MD

    The primary intent of this multi-center, prospective, descriptive, observational study is to determine the performance characteristics of ultrasound and magnetic resonance imaging to accurately diagnose fetal aqueductal stenosis. 

  10. Introduction of Novel Care Delivery Methods in the Peripartum Setting to Improve Mental Health

    Principal Investigators: Sanaa Suharwardy, MD; Amy Judy, MD

    The purpose of the study is to evaluate whether mental health evaluation and treatment can be improved in a population of women during pregnancy and after delivery using different methods of care delivery, including use of a conversational mental health chatbot. 

  11. Sepsis Markers in Pregnancy

    Principal Investigators: Samantha Do, MD; Natali Aziz, MD

    In nonpregnant patients, validated markers, such as lactate and procalcitonin, exist that aid in the diagnosis and management of sepsis. Normal levels of lactate and procalcitonin have not yet been established for pregnant women in the peripartum period, thus, we aim to prospectively trend these markers and compare levels in women with and without infection during labor.

  12. Maternal Telomere Length in Pregnancy

    Principal Investigators: Danielle Panelli, MD; Katherine Bianco, MD

    The purpose of the study is to evaluate the relationship between maternal telomere length and the physiologic effects of pregnancy.

  13. High Sensitivity Flow Imaging of the Human Placenta with Coherence-Based Doppler

    Principal Investigators: Jeremey Dahl, PhD; Virginia D. Winn, MD, PhD

    The purpose of this study is to compare the sensitivity of a new ultrasound imaging modality, called coherent flow power Doppler imaging, to a conventional ultrasound imaging technique, called power Doppler imaging. The study will compare sensitivity by measuring the ability of each imaging technique to detect and observe changes in the spiral arteries of the placenta.