Research

A Multicenter, Observational Cohort Study of Women Receiving Standard of Care (SOC) for the Treatment of Pelvic Pain Attributable to Suspected or Confirmed Endometriosis (P16-836)

The purpose of this study is to understand historic, current and evolving treatment pathways, treatments and interventions in women with a suspected or confirmed diagnosis of Endometriosis.

Principal Investigator: Deirdre Lum, MD

EMPOWER: Endometriosis diagnosis using MicroRNA: PrOspective study in Women to allow Early disease Recognition

Dot Laboratories is developing a diagnostic test (DotEndo) to help doctors diagnose endometriosis. The purpose of this research is to collect blood and saliva samples from women who are planning to have a laparoscopy or other surgical procedure. The blood and saliva samples will be used to develop the Dot Laboratories diagnostic test.

This study is actively recruiting patients of Drs Atashroo and Lum who are scheduled to undergo laparotomy or laparoscopy for either signs and symptoms of suspected endometriosis or for other gynecologic conditions. Please email gynresearch@stanford.edu for more information.

Principal Investigator: Diana Atashroo, MD

A Phase 3, Open-label, Multi-center, Single Arm Study to Assess Contraceptive Efficacy and Safety of the Etonogestrel (MK-8415) Implant During Extended Use From 3 Years After Insertion in Females 35 Years of Age or Younger

The objective of this study is to assess the efficacy, safety, tolerability of using the etonogestrel implant (MK-8415) for more than 3 years, up to 5 years.

The study will recruit participants who are 35 years of age or younger, have a palpable ENG implant (also known as Nexplanon) that is 36 months (±2 weeks) from the date of insertion, doesn’t desire pregnancy in the next 24 months, and are in a good physical and mental health. Please email birthcontrol@stanford.edu for more information.

Principal Investigator: Paul Blumenthal, MD, MPH

Cabergoline for Lactation Inhibition after Second-Trimester Abortion or Loss (LISTA)

The purpose of this study is to asses the effectiveness of cabergoline, a medication routinely used to treat a type of brain tumor that secretes the same hormone that causes milk secretion, in preventing breast engorgement after second-trimester abortions and stillbirth.

The study is recruiting patients presenting to Stanford gynecology clinic for second-trimester terminations. Please email birthcontrol@stanford.edu for more information.

Principal Investigator: Andrea Henkel, MD

Access to reproductive health care during the COVID-19 pandemic: Experiences and preferences for future care

The purpose of this study is to assess the reproductive health experiences and preferences of medication abortion clients accessing care during the COVID-19 pandemic. We hypothesize that clients will be favorable of options like at home pregnancy tests that do not require an in-person evaluation. We will use these findings to call for more person-centered follow-up options to become available on a policy level.

This study is actively recruiting patients presenting to Stanford gynecology clinic or Emma Goldman clinic in Iowa for a first trimester medication abortion. Please email birthcontrol@stanford.edu for more information.

Principal Investigator: Paul Blumenthal, MD, MPH

CELLEBRATE: An Adaptive, Two Stage, Double-Blind, Stratified, Randomized, Controlled Trial Comparing the Safety and Efficacy of AMDC-USR with Placebo in Female Subjects with Stress Urinary Incontinence

The purpose of this study is to evaluate the safety and efficacy of muscle derived cells for bladder opening repair. Muscle cells will be harvested by thigh muscle biopsy from patients who suffer from stress urinary incontinence. The cells will be grown out until there is an adequate amount of cells and injected around the patient’s bladder opening with their own cells.

This study is actively recruiting women between the ages of 50-75 who suffer from stress urinary incontinence. Please email gynresearch@stanford.edu for more information.

Principal Investigator: Eric Sokol, MD

Lessening Incontinence through Low-impact Activity (LILA)

The purpose of the study is to examine the use of yoga and physical conditioning and effects it has in reducing episodes of both stress and urge incontinence in women. Participants will be randomized to either practice yoga or physical conditioning in virtual group sessions twice a week, for 12 weeks.

This study is actively recruiting women 45+ years old who suffer from stress urinary incontinence. Please email gynresearch@stanford.edu for more information.

Principal Investigator: Leslee Subak, MD

Randomized, Comparator-Controlled, Single Blinded, Multicenter Study Evaluating the Efficacy and Safety of Yōni.Fit^® in Women with Stress Urinary Incontinence (SUI)

The purpose of this study is to evaluate the safety and effectiveness of Yōni.Fit^® Test device compared to Yōni.Fit^® Comparator device, in temporary management of stress urinary incontinence in women. The Yōni.Fit^® Bladder Support is 100% medical grade silicone, collapsible device placed into the vagina to provide urinary continence. It has the distinct advantage of being minimally invasive and may provide immediate relief of the symptoms of stress urinary incontinence.

This study is actively recruiting adult women who suffer from stress urinary incontinence. Please email gynresearch@stanford.edu or visit LeakyLady.com for more information.

Principal Investigator: Eric Sokol, MD

Evaluation of the TheraNova Neuromodulation System for the Treatment of Overactive Bladder Symptoms

The purpose of this study is to evaluate the safety and effectiveness of the TheraNova Neuromodulation System at decreasing symptoms related to overactive bladder (OAB). The TheraNova Neuromodulation System is being developed as a non-invasive treatment similar to a TENS unit to reduce OAB symptoms and participation includes self-administering one 30-minute treatment three times per week for 12 weeks.

This study is actively recruiting adult women who suffer from overactive bladder (OAB) with urge urinary incontinence or mixed urinary incontinence. Please email gynresearch@stanford.edu for more information.

Principal Investigator: Eric Sokol, MD